Cardioactive drugs
نویسندگان
چکیده
منابع مشابه
Cardioactive drugs.
Most patients who have taken a large dose of a beta-blocker will demonstrate bradycardia and hypotension. With very large doses there will be coma, convulsions and profound hypotension. A variety of cardiac dysrhythmias and ECG abnormalities are described. The more serious of these can result in cardiorespiratory arrest.2,3 These include: heart block intraventricular conduction defects ST...
متن کاملThe heart of Daphnia magna: effects of four cardioactive drugs.
We used Daphnia magna bioassays to determine the LC(50) and the effects on the heart of the cardioactive drugs ouabain, verapamil, metaproterenol and metoprolol. Distinctions were made between the pharmacological and toxicological effects of these drugs and the adequacy of physicochemical characteristics of its habitat (reconstituted water). Video microscopy and digital image processing were us...
متن کامل65: Cardioactive Steroids
The Ebers Papyrus provides evidence that the Egyptians used plants containing cardioactive steroids (CASs) at least 3000 years ago. However, it was not until 1785, when William Withering wrote the first systemic account about the effects of the foxglove plant, that the use of CASs was more widely accepted into the Western apothecary. Foxglove, the most common source of plant CAS, was initially ...
متن کاملThe effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.
Developing effective drug therapies for arrhythmic diseases is hampered by the fact that the same drug can work well in some individuals but not in others. Human induced pluripotent stem (iPS) cells have been vetted as useful tools for drug screening. However, cardioactive drugs have not been shown to have the same effects on iPS cell-derived human cardiomyocytes as on embryonic stem (ES) cell-...
متن کاملMachine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs
Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically relevant preclinical or patient-specific screening to detect potential cardiotoxic effects of drug candidates may be possible. However, one of the persistent challenges for developing a high-throughput drug screening plat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Medicine
سال: 2003
ISSN: 1470-2118,1473-4893
DOI: 10.7861/clinmedicine.3-2-127